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Pablo Empanada
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Drug made from toxic weed kills cancer

In laboratory studies, the researchers say, a three-day course of the drug G202 shrunk human prostate tumors grown in mice by an average of 50 percent within 30 days. It far outperformed docetaxel, a chemotherapy drug now used against prostate cancer, and was also highly effective against animal models of human breast cancer, kidney cancer, and bladder cancer.

The study by scientists at the Johns Hopkins Kimmel Cancer Center and from Denmark was published in the journal Science Translational Medicine.

thapsia_11.jpg

G202 is derived from Thapsia garganica, a weed that grows in the Mediterranean region. The plant makes a product—dubbed thapsigargin—that since the time of ancient Greece has been known to be toxic to animals. In Arab caravans, the plant was known as the “death carrot” because it would kill camels that ate it, the researchers noted.

“Our goal was to try to re-engineer this very toxic natural plant product into a drug we might use to treat human cancer,” says lead study author Samuel Denmeade, professor of oncology, urology, and pharmacology and molecular sciences at Johns Hopkins. “We achieved this by creating a format that requires modification by cells to release the active drug.”

By disassembling thapsigargin and chemically modifying it, the researchers created a form that Denmeade likens to a hand grenade with the pin in. The drug can be injected and travel through the bloodstream without harming healthy blood vessels and tissues.

But when G202 finds cancer tumors, a protein released by the tumors (called prostate-specific membrane antigen), in effect “pulls the pin.” That releases cell-killing agents from the drug into the tumor and the blood vessels that feed it, as well as to other cells in the vicinity. Specifically, G202 blocks the function of another protein—the SERCA pump—that is necessary for cell survival, the researchers report.

“The exciting thing is that the cancer itself is activating its own demise,” says senior study author John Isaacs, professor of oncology, urology, and chemical and biomedical engineering at Johns Hopkins.

Based on their laboratory results, Johns Hopkins physicians have performed a phase I clinical trial to assess safety of the drug and have treated 29 patients with advanced cancer. In addition to Johns Hopkins, the University of Wisconsin, and the University of Texas-San Antonio are participating in the trial. A phase II trial to test the drug in patients with prostate cancer and liver cancer is planned.

Because G202 targets the SERCA pump, which all cells need to stay alive, researchers say it will be difficult for tumor cells to become resistant to the drug.

The study’s co-authors are from Johns Hopkins, the Danish National Research Foundation, Aarhus University, and the University of Copenhagen, and GenSpera Inc.

The work was supported by the Department of Defense Prostate Cancer Research Program, the Prostate Cancer Foundation and David Koch, the Danish Cancer Society, the Danish Research Council for Strategic Research, the Danish National Research Foundation, the Danish Medical Research Council, the Aarhus University Research Foundation, and National Cancer Institute.

Denmeade and Isaacs are consultants for GenSpera Inc. and have received equity and financial compensation. This relationship has been disclosed and is under the management of the Johns Hopkins University School of Medicine Conflict of Interest Committe

http://www.futurity....d-kills-cancer/

Edited by Pablo Empanada
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Ja se sabia disto a muito tempo

Ja no ano passado ouve um documentario sobre um grupo de jovens cientistas que conseguiram alcançar resultados positivos usando exactamente a mesma coisa mas a situação foi "abafada" nos states por causa das pressões das farmacêuticas :)

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Ouvi falar de várias toxinas que podem ser alteradas para fins medicinais..segundo o que eu percebi..explicando de forma simples...as toxinas são semelhantes as proteínas..as proteinas são responsaveis pela comunicação para com as celulas, por exemplo um veneno que te paralisa os musculos, funciona assim...o corpo aceita a toxina como uma proteina mascarada..mas a informação é errada..e as celulas responsaveis pela coordenação dos musculos falham..começas a ter espasmos..e falta de ar porque os pulmões não enchem....mas se conseguires por exemplo falando de um veneno..que é um conjunto de várias toxinas..milhares alguns....se conseguires isolar as certas...podes..ou melhor já foram criados medicamentos para tratar rapidamente de enfartes...certos tipos de cancro...e certas doenças...com taxas de eficácia bem superiores aos medicamentos actuais

http://listverse.com/2009/09/14/10-poisons-used-to-save-lives/

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nao tem muito a ver mas ja que falaram das farmaceuticas, vao mais a fundo e investiguem sobre a FDA e as companhias quimicas americanas, onde o protector solar, sim o protector solar, é a prova provada do monopolio que existe em torno da industria quimica e de como se proibe o uso e venda de protectores 100% naturais (que já foram inventados).

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Curiosamente deu recentemente um documentario na SicNoticias sobre um medicamento fabricado para o mundo inteiro por uma empresa Francesa, o Mediator.

Resumidamente essa empresa era e é protegida pela estado com muitas ligações politicas mesmo com os primeiros ministros. O medicamento facilmente teve aprovacao pelos organismo incluindo a FDA dos EUA.

Medicos franceses começaram a descobrir que o medicamento provocava problemas sérios no coração que podia levar à morte e rapidamente o organismo responsável pela aprovação dos medicamentos em frança descartou os indícios.A empresa tem varios médicos "espioes" em todos os organismo responsaveis pelo controlo e aprovacao, medicos a testemunhar contra tiveram que ter guarda-costas durante meses e ainda hoje estão em tribunal.

Esteve no mercado durante 40+anos e só em frança foi consumido pelo menos por 5 milhões de pessoas e estima-se que provocou a morte até agora de 2000 pessoas.

Só foi erradicado do mercado francês porque uma médica lutou sozinha sem nunca desistir durante anos.

Jacques Servier, the founder of Servier Laboratories which produced Mediator, is being investigated on suspicion of dishonest practices, deception over the drug's quality, and of falsely obtaining authorization to sell it.

A trial is expected in May.

Mediator - mostly prescribed by doctors as a weight-loss pill - was sold to as many as 5 million people in France between 1976 and November 2009, when it was withdrawn, years after being pulled in Spain and Italy. State health inspectors have said the drug should have been retired in France a decade earlier.

According to the French health ministry, at least 500 people died of heart valve trouble in France because of exposure to Mediator's active ingredient, benfluorex. Other estimates based on extrapolations put the death toll closer to 2,000.

Servier denies having misled authorities and patients. The company recognizes 38 deaths linked to the drug, but says only four of these were caused by it.

The Mediator scandal - which has already prompted the resignation of the head of Afssaps - is France's worst in years.

President Nicolas Sarkozy has promised to shake up the healthcare system and make it more transparent in response to a slew of lawsuits filed by groups of victims' families.

Servier, 89, was awarded France's national merit medal, the Legion d'Honneur, by Sarkozy - who was once his lawyer - less than a year before the drug was pulled.

"Foi comercializado em Portugal entre 1977 e Novembro de 2009.Foi uma médica francesa, Irene Franchon, que detectou o primeiro caso, em 2007. No entanto, só dois anos depois é que a Agência Europeia do Medicamento (EMEA) desencadeou a investigação que culminou na proibição de venda" "

Além disso, o jornal revela uma carta subscrita em 1998 por três prestigiados médicos franceses à Agência Nacional de Drogas (ANF), na qual alertavam para os riscos do Mediator, produto que só viria a ser retirado do mercado em 2009."

Ao pesquisar encontrei este site onde nos comentários de 2011 se pode ler:

Eu tomei este medicamento, durante 7 meses, entre Setembro 2009 e Maio 2010, tenho tido vários problemas de saúde e certos sintomas, que reconheço nas descrições feitas por alguns pacientes, fui ver o meu médico de família que me prescreveu este medicamento, que me diz que não vê nada de especial, que está tudo bem! Será que é mesmo assim? Eu penso que não! para a farmácia me ter vendido este medicamento, em janeiro e abril 2010, deu prioridade ao interesse financeiro e não á saude dos pacientes!

Provavelmente conhecidos vossos o tomaram, era prescrito ca por médicos para perda de peso e diabéticos. Suspeito existir ca um grande numero de problemas de saúde e mortes que não foram ligadas ao medicamento

Isto foi um verdadeiro abre olhos.. Não se pode confiar no que o médico receita e diz ser seguro...

http://www1.ionline....ardiacos-graves

http://www.tvi24.iol...09397-4071.html

http://www.dn.pt/ini...6&seccao=Europa

http://www.infarmed....?itemid=2280422

Edited by Pablo Empanada
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